Multicomponent Modular Synthesis of Chiral Bicyclic Bridged Compounds via an Alkenylfuran-Based Acylation/Rearrangement/Cyclization Sequence
The catalytic asymmetric multicomponent acylation/rearrangement/cyclization of alkenylfurans with acyl oxime esters/arylamines or acyl oxime esters/arylamines/hydroxylamine has been developed. This method employs synergistic photoredox/Brønsted acid catalysis, enabling the efficient and versatile synthesis of multifunctionalized [3.2.1] and [4.2.1] bicyclic bridged compounds in high yields with excellent diastereo- and enantioselectivities.
Authors
- Yunfei Cai (ORCID: https://orcid.org/0000-0003-4823-8221)
- Kexin Yang (ORCID: https://orcid.org/0000-0003-2333-2406)
- Yurong Tang (ORCID: https://orcid.org/0000-0002-4183-8008)
- Yu Tian (ORCID: https://orcid.org/0000-0002-0253-6883)
- H. Tao
Institutions
- Chongqing University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1021/acs.orglett.4c04709
- Citations
- 6
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 5.62
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Venture and Innovation Support Program for Chongqing Overseas Returnees