Exposure to major coronary heart disease events reduces lung cancer risk: a mendelian randomization study based on a European population
This study suggests that MCHDE reduce the risk of NSCLC in the U.K. population and SCLC in the Finnish population. However, given that the underlying mechanism through which MCHDE reduces the risk of NSCLC and SCLC remains unclear, it is premature to conclude that individuals exposed to MCHDE do not require lung cancer screening.
Authors
- Hongting Lu
- Zhiwen Zheng (ORCID: https://orcid.org/0000-0001-5982-0968)
- Zhanyu Xu (ORCID: https://orcid.org/0000-0002-6471-1667)
- Xiaohong Duan (ORCID: https://orcid.org/0000-0002-6747-1734)
- Tiaozhan Zheng
- Shikang Li (ORCID: https://orcid.org/0000-0002-8187-3676)
- Xinhuai Ou
- Dongming He
Institutions
- Guangxi Medical University (CN)
- Guangxi Zhuang Autonomous Region Health and Family Planning (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1186/s12885-025-13485-6
- Citations
- 3
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province
- Guangxi Medical University
- Youth Science Foundation of Guangxi Medical University