WCN25-1928 Clustering patients with chronic kidney disease based on routinely measured laboratory biomarkers and its association with disease progression; findings from a population level feasibility study from British Columbia, Canada

the study period.Nephrotic syndrome is defined in children by 24hour proteinuria greater than or equal to 50 mg/kg/24 hours, hypoalbuminemia less than 25-30 g/l and hypoproteinemia less than 50-55 g/l.Results: A total of 26 patients had fulfilled the inclusion criteria, with a hospital prevalence of 0.69%.The males predominated with male to female ratio of 1.3.Most children were aged 5 to 10 years (57.69%).The mean age at diagnosis was 8 AE 2.9 years.In the majority of cases (61.54%) the delay between the onset of symptoms and the first consultation was more than 14 days.Edema was found in all patients at the time of consultation.The 24-hour proteinuria was between 50 to 100 mg / kg / day in 65% of cases with an average of 100.16AE 47.64 mg / kg / d.Mean serum protein and albumin were respectively 41.19 AE 12.41g / L and 18.46 AE 5.97g / L. The NS was pure in 15 patients or in 57.69% of cases and impure in 11 patients or in 42.31% of cases.Treatment was based on oral corticosteroid therapy (prednisolone) at a dosage of 2 mg/kg/day.Steroid sensitivity was observed in 22 patients, i.e. 84.61%, one child was steroid dependent (3.85%) and two children were steroid resistance, i.e. 7.69%.One child died due to severe renal impairment (mortality of 3.85%).Only one patient had benefited from a renal biopsy.Conclusions: NS remains common in children at the HNZ.The improvement of the technical platform for PBR and anatomopathological examinations as well as the establishment of social security prove necessary for a better management of SN in children at the HNZ.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.