WCN25-1602 "Epigenetic and Metabolic Regulation: The Role of HDAC2 and AMPK1 in Drug Resistance in Steroid Resistant Nephrotic syndrome"
Drug resistance remains a formidable challenge in the treatment of various diseases. The action of glucocorticoids is to switch off activated inflammatory genes. The activated glucocorticoid receptors (GR) interact with co-repressor molecules to impair NFκB-associated coactivator activity, reducing histone acetylation, chromatin remodelling. Reduction in histone acetylation occurs via recruitment of histone deacetylase (HDAC) 2 to the activated inflammatory gene complex by activated GR, resulting in efficacious suppression of activated inflammatory genes within the nucleus.
Authors
- Vikas Agarwal (ORCID: https://orcid.org/0000-0002-4508-1233)
- Harshit Singh (ORCID: https://orcid.org/0000-0002-7190-3325)
- Atul Atul
- Saurabh Chaturvedi (ORCID: https://orcid.org/0000-0001-7832-3772)
- Akhilesh Jaiswal
- Narayan Prasad
Institutions
- Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
- Centre of Biomedical Research (IN)
- Defence Institute of Psychological Research (IN)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.ekir.2024.11.334
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00