WCN25-4202 NAVIGATING THE THERAPEUTIC LANDSCAPE: A RETROSPECTIVE EXPLORATION OF TREATMENT OUTCOMES IN PRIMARY MEMBRANOUS NEPHROPATHY

ANCA status: negative -in one family (EGPA), MPO-or pANCA in 6 families, pr3-or cANCA in 6.In one family one relative had MPO-ANCA and another pr3-ANCA.Among the reported manifestations, lung, kidney, ENT, and general manifestations were the most common, followed by skin, nervous system, GI tract, and cardiovascular involvement (Figure 1).AAV manifestations varied between the members of the same family, however in six families identical presentation with the involvement of the same organs and systems was reported.Conclusions: Familial cases of AAV demonstrate clinical and serological heterogeneity among the affected relatives with a high prevalence of kidney and lung involvement.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.