WCN25-2987 2 CASES WITH IGM NEPHROPATHY

and magnesium (43 mg/dl) excretion were reduced, consistent with a Gitelman phenotype.Urinalysis revealed nephrotic-range proteinuria with active sediment, while other laboratory values were within normal limits.A renal biopsy demonstrated mesangial (M1) and endocapillary proliferation (E1), with no evidence of segmental sclerosis (S0) or crescents (C0).The degree of interstitial fibrosis and tubular atrophy was less than 10% (T0).Immunofluorescence showed dominant mesangial IgA deposits.The patient was managed with telmisartan and eplerenone, along with potassium and calcium supplementation.Corticosteroids were initiated due to persistent proteinuria and tapered off over six months.At the latest follow-up, the patient achieved complete remission with normalization of electrolyte levels.Conclusions: Although rare, the coexistence of IgA nephropathy and Gitelman syndrome has been documented.It is imperative to consider renal biopsy in cases of Gitelman syndrome presenting with significant proteinuria, particularly nephrotic-range proteinuria, to elucidate the underlying pathology.Further studies are required to determine whether this coexistence is merely coincidental or suggests a potential pathophysiological association.I have no potential conflict of interest to disclose.I used generative AI and AI-assisted technologies in the writing process.