WCN25-2101 Association of IL-10 gene promoter polymorphisms (-592A/C; -819C/T) with diabetic nephropathy in type 2 diabetes mellitus among the South Indian population
Background: Diabetic nephropathy is a leading cause of end-stage kidney disease globally. Genetic polymorphisms, as well as metabolic and hemodynamic homeostasis, are major factors in the development and progression of DN. Recent studies have shown that interleukin-10 polymorphic variants are associated with cytokine production, renal hypertrophy, and the onset of nephropathy.
Authors
- Ramprasad Elumalai (ORCID: https://orcid.org/0000-0003-2399-1698)
- Gnanasambandan Ramanathan (ORCID: https://orcid.org/0000-0002-4361-6679)
- Patel Apurva A
- Entsar A. Saad (ORCID: https://orcid.org/0000-0001-6477-8098)
- Sandhya Suresh (ORCID: https://orcid.org/0000-0001-8821-0579)
- M Jaykumar
Institutions
- Chennai Mathematical Institute (IN)
- Sri Ramachandra Institute of Higher Education and Research (IN)
- Chettinad Health City (IN)
- Vellore Institute of Technology University (IN)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.ekir.2024.11.499
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00