WCN25-1222 The spectrum of Nondiabetic Renal Disease in Diabetes

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) worldwide, largely due to the increasing prevalence of type 2 diabetes mellitus (DM). Factors such as glomerular hyperfiltration, capillary hypertension, and chronic hyperglycaemia, with podocyte injury, play a key role in kidney damage. However, non- diabetic renal diseases (NDRD) often present similarly to DN and are frequently underdiagnosed. A considerable number of diabetic patients may have NDRD, which challenges the common attribution of proteinuria or renal failure solely to DN.