WCN25-3170 FULMINANT SYSTEMIC LUPUS ERYTHEMATOSUS: A CASE REPORT HIGHLIGHTING MULTI-ORGAN INVOLVEMENT AND THERAPEUTIC CHALLENGES

In pFSGS, WT1 was negatively correlated with desmin (-0.74, p<0.05) that predominantly localised in WT1-negative glomerular areas by confocal microscopy (Figure 4).Decreased WT1 and increased desmin in the parietal epithelium were also found to characterise pFSGS (Fig. 1).Conclusions: Bidirectional alterations in the glomerular expression of podocyte markers (WT1, Nphs2) and intermediate filament proteins are apparent in pFSGS.These findings could suggest for the epithelialmesenchymal transition of podocytes and the parietal epithelium, determining the structural and functional disorders of these cells.