WCN25-2158 DESIDUSTAT IN ERYHTROPOETIN INDUCED PURE RED CELL APLASIA IN DIALYSIS-DEPENDENT CKD PATIENTS: A CASE REPORT

proliferative effects.It also promotes excessive free radical formation and platelet activation.This study aims to determine the direct correlation between serum phosphate levels and endothelial dysfunction, as indicated by serum endothelin-1 levels.Methods: In this prospective cohort study, 37 participants with CKD stage 5 undergoing maintenance hemodialysis were enrolled, all of whom had recent reports of hyperphosphatemia.Following informed consent, serum phosphate levels (measured using the phosphomolybdate complex method) and endothelin-1 levels (measured using the ELISA method) were assessed.Hyperphosphatemia was managed with dietary modifications and sevelamer at doses of 1200 to 2400 mg.After 6 months, serum phosphate and endothelin-1 levels were re-evaluated, and changes in their values were recorded.Statistical analysis was conducted using SPSS software, and Spearman's correlation was employed to analyze the relationship between changes in serum phosphate and endothelin-1 levels. Results:Conclusions: A significant positive correlation was observed between changes in serum phosphate and endothelin-1 levels (p < 0.001).This study indicates that hyperphosphatemia is associated with endothelial dysfunction, as measured by serum endothelin-1 levels.Chronic endothelial dysfunction can lead to vascular complications such as calcification and accelerated atherosclerosis.