WCN25-1101 ANTI-CD45 STAINING IN RENAL HISTOPATHOLOGY AS A PREDICTOR OF CLINICAL PRESENTATION AND SHORT-TERM OUTCOME IN LUPUS NEPHRITIS

Systemic lupus erythematosus (SLE) commonly affects the kidney, when it is known as lupus nephritis (LN). Despite treatment, about 30% of LN patients progress to end stage renal disease (ESRD) within 10 years after the disease onset. Renal histopathology is the best way to detect and classify LN. With the current histopathological techniques and markers, assessing disease activity and predicting outcome is often difficult. Use of anti-CD45 staining in renal histopathology as a newer marker to assess tubulointerstitial involvement and predict clinical outcome independent of International Society of Nephrology / Renal Pathology Society (ISN/RPS) classification has shown promise in LN.