WCN25-2130 A STUDY TO CORRELATE SERUM PHOSPHORUS WITH MARKER OF ENDOTHELIAL CELL DYSFUNCTION IN CHRONIC KIDNEY DISEASE PATIENTS ON MAINTENANCE HAEMODIALYSIS

Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) is a systemic condition characterized by disturbances in mineral and bone metabolism due to chronic kidney disease (CKD). As the glomerular filtration rate declines, phosphate excretion diminishes, leading to elevated serum phosphate levels. Hyperphosphatemia profoundly affects vascular cell behavior and function and is associated with cardiovascular diseases, particularly through vascular calcifications in CKD patients [1]. Research indicates that high serum phosphate levels can impair endothelial function by reducing nitric oxide (NO) release through the inhibitory phosphorylation of endothelial nitric oxide synthase (eNOS) [2].