WCN25-2348 Gender differences in alkali requirement for correcting Metabolic acidosis in predialysis Chronic Kidney Disease

Men and women respond differently to catabolic conditions. It is postulated that females tolerate chronic inflammation to a lesser degree than males. Apart from kidney disease disease per se, the response of women to metabolic acidosis(MA) can be modified by gender-related factors like low muscle mass and gonadal hormones. There is no data on the gender differences for alkali supplementation to correct MA. The present study looks in to the gender differences in bicarbonate requirements for correction of MA in pre-dialysis Chronic Kidney Disease.