WCN25-1387 DIFFUSE ALVEOLAR HEMORRHAGE AS AN ATYPICAL PRESENTATION FOR IgA NEPHROPATHY: CASE REPORT

Results:95 diabetic patients were included in our analyses.Median age was 56 years.52% were male.Comorbidities included hypertension in 84%, coronary artery disease in 5.2% , hypothyroidism in 5.2%.46% were on RAS inhibitors and 33.7% were on SGLT2 inhibitors at the time of analysis.Median eGFR was 28 ml/min/1.73m 2by CKD EPI.As per KDIGO CKD stages as per glomerular filtration rate 2.4% 6%,40.9%,26%24% were present in G1,G2, G3, G4 and G5.87.3% patients were found to have albuminuria ( KDIGO A2-18.9%,KDIGO A3-68.4%).The point of care test was found to have a sensitivity of 77%, specificity of 54%, a positive predictive value of 92% and negative predictive value of 24%.The co-relation coefficient between the quantitative UACR values by point of care test and by laboratory method was 0.014.Conclusions: The point of care kidney care test can be used to detect albuminuria in diabetic patients.Considering the high positive predictive value, it may be used to start antiproteinuric therapy (if found to be positive) such as SGLT2i , RASi or mineralocorticoid antagonist in resource constrained settings.A negative test however needs to be confirmed by a laboratory estimation.The quantitative value should be confirmed by a laboratory estimation for titration of dose of medications in patients already on antiproteinuric therapy.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.

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Journal
Kidney International Reports
Published
2025-01-27
DOI
https://doi.org/10.1016/j.ekir.2024.11.293
Primary Topic
Renal Diseases and Glomerulopathies
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article

WCN25-1387 DIFFUSE ALVEOLAR HEMORRHAGE AS AN ATYPICAL PRESENTATION FOR IgA NEPHROPATHY: CASE REPORT

Lilia María Rizo Topete, José Escobar, Rogelio de Jesús Castor Hernández, Mara Cecilia Olivo Gutiérrez et al.
Kidney International Reports
Renal Diseases and Glomerulopathies
article

WCN25-1387 DIFFUSE ALVEOLAR HEMORRHAGE AS AN ATYPICAL PRESENTATION FOR IgA NEPHROPATHY: CASE REPORT

Lilia María Rizo Topete, José Escobar, Rogelio de Jesús Castor Hernández, Mara Cecilia Olivo Gutiérrez, María Virgilia Soto Abraham, Paola Borbolla Flores, E Moreno González
article en

Abstract

Results:95 diabetic patients were included in our analyses.Median age was 56 years.52% were male.Comorbidities included hypertension in 84%, coronary artery disease in 5.2% , hypothyroidism in 5.2%.46% were on RAS inhibitors and 33.7% were on SGLT2 inhibitors at the time of analysis.Median eGFR was 28 ml/min/1.73m 2by CKD EPI.As per KDIGO CKD stages as per glomerular filtration rate 2.4% 6%,40.9%,26%24% were present in G1,G2, G3, G4 and G5.87.3% patients were found to have albuminuria ( KDIGO A2-18.9%,KDIGO A3-68.4%).The point of care test was found to have a sensitivity of 77%, specificity of 54%, a positive predictive value of 92% and negative predictive value of 24%.The co-relation coefficient between the quantitative UACR values by point of care test and by laboratory method was 0.014.Conclusions: The point of care kidney care test can be used to detect albuminuria in diabetic patients.Considering the high positive predictive value, it may be used to start antiproteinuric therapy (if found to be positive) such as SGLT2i , RASi or mineralocorticoid antagonist in resource constrained settings.A negative test however needs to be confirmed by a laboratory estimation.The quantitative value should be confirmed by a laboratory estimation for titration of dose of medications in patients already on antiproteinuric therapy.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.

Kidney International ReportsVol. 10(2)
Hospital Universitario Dr José Eleuterio Gonzalez (MX), Instituto Nacional de Cardiología (MX)
Zero hunger
Openalex Percentile: Top 98%
Renal Diseases and Glomerulopathies
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