WCN25-3344 EFFECT OF TUNNELED HEMODIALYSIS CATHETER ANTIMICROBIAL LOCK SOLUTION (TAUROLIDINE)IN PREVENTION OF CATHETER RELATED BLOOD-STREAM INFECTION AD ITS IMPACT ON REDUCTION OF TREATMENT COST

Central venous catheters remain a common form of vascular access for patients with chronic hemodialysis,widespread application of central venous catheters exposes patients to an enhanced risk for catheter-related infection,which includes catheter-related bloodstream infection and exit-site infection.Many guidelines state that the use of pure heparin is no longer the gold standard but the guidelines do not provide a clear recommendation regarding the variation and availability of catheter lock solution.Taurolidine,a derivative of the amino acid taurine,is an antimicrobial lock solution and has broad-spectrum antibacterial activity against gram positive and gram-negative bacteria and fungi (such as Candida) (including MRSA and VRE) by the binding of its hydroxymethyl group to cell walls, proteins, and cytotoxins.