WCN25-4450 UREMIA, ANGIOPLASTY INJURY AND VESSEL TYPE (ARTERY VS VEIN) ACTIVATE DIFFERENTIAL GENE EXPRESSION AND PATHWAY PROFILES: ? ROLE IN VASCULAR DISEASE AND VASCULAR ACCESS DYSFUNCTION IN ESKD

peripheral vasoconstriction leading to a reduced dissipation of heat from the skin.In this poster, we present a 55-year-old female with endstage renal disease (ESRD) secondary to hypertension who developed urticaria during a hemodialysis session.Methods: The patient had been undergoing hemodialysis for two years through a left arteriovenous fistula.During the first 15 minutes of the session, she developed a skin rash with itchy wheals on her upper limbs, soon it spread to involve her trunk, and it was associated with erythema.The patient was given chlorpheniramine and hydrocortisone to relieve the symptoms.Despite this treatment, the symptoms persisted, leading to the cessation of her dialysis session prematurely, and the patient was transferred to the emergency department for further evaluation.Results: Investigations were conducted to determine the underlying cause of the allergic reaction, including reviewing dialysate components, patient medications, and potential allergens.Where patient was recently on Elisio 19H dialyzer, After the urticaria episode, the dialyzer was changed to Solace 19H dialyzer with no further urticaria reaction noted.That's why a collaboration of multidisciplinary team is needed, for prevention in dealing with such cases in the future.Conclusions: This case shed light on the circumstances of urticaria in hemodialysis patients and the challenges in controlling and dealing with allergic reactions.To prevent any further complications immediate recognition and intervention are required.The continuation of symptoms despite antihistamine and corticosteroid treatment suggests that comprehensive investigations should be taken to identify potential triggers in dialysis settings.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.