WCN25-907 CLINICAL CHARACTERISTICS IN CHILDREN WITH MONOGENIC AND NON-GENETIC STEROID-RESISTANT NEPHROTIC SYNDROME DUE TO FOCAL SEGMENTAL GLOMERULOSCLEROSIS TREATED WITH CALCINEURIN INHIBITORS

Сalcineurin inhibitors (CNI) are currently being considered as the first line immunosuppressive treatment for steroid-resistant nephrotic syndrome (SRNS) in children without a proven genetic cause. According to the latest data, CNI could induce remission and improve outcome in some cases with monogenic SRNS. It remains unclear whether children with monogenic SRNS had higher risk of CNI-induced nephrotoxicity (CNIT). The aim of the study was to compare clinical characteristics in children with monogenic and non-genetic SRNS due to focal segmental glomerulosclerosis (FSGS) treated with CNI.