WCN25-2910 Unraveling the Collapse: Outcomes of Collapsing Glomerulopathy in Renal Transplants

Collapsing glomerulopathy (CG) is a distinct and aggressive variant of focal and segmental glomerulosclerosis (FSGS), characterized clinically by heavy proteinuria, rapid decline in renal function, and progression to end-stage renal disease (ESRD). Histologically, CG is defined by segmental or global collapse of glomerular capillaries, hypertrophy and hyperplasia of visceral epithelial cells, and marked tubulointerstitial injury, including microcystic tubular dilatation. The clinical impact of CG in renal allograft biopsies is not fully elucidated, with limited data on its incidence and outcomes in transplant recipients.This study aimed to determine the prevalence, clinicopathological characteristics, and outcomes of CG in renal transplant recipients, based on allograft biopsy findings.