WCN25-1853 MICA and NKG2D Gene Polymorphisms Influence Chronic Rejection, Graft Function, and Response to Therapy in Kidney Transplantation
Chronic antibody-mediated rejection is a significant cause of kidney transplant failure. Traditionally, compatibility between the HLA system of the donor and recipient has been considered the most important genetic factor in reducing the risk of rejection. Recent studies have shown that other factors, such as the major histocompatibility complex (MHC) class I MICA gene can also influences the transplantation outcome. However, the role of the primary MICA receptor, NKG2D, has yet to be explored.We aimed to investigate the correlation between recipient/donor MICA allele matching and NKG2D genotype with the risk of chronic antibody-mediated rejection and their potential clinical effects and implications for organ maintenance therapy.
Authors
- Sara Lai (ORCID: https://orcid.org/0000-0002-8040-0631)
- Gianfranca Cabiddu (ORCID: https://orcid.org/0000-0003-1145-7404)
- Maurizio Melis (ORCID: https://orcid.org/0000-0002-5857-781X)
- M. M. Lorrai
- Sabrina Giglio (ORCID: https://orcid.org/0000-0002-3954-326X)
- Caterina Mereu (ORCID: https://orcid.org/0009-0006-2588-6807)
- Nicola Lepori (ORCID: https://orcid.org/0000-0002-3133-6565)
- Davide Argiolas
- Cristina Manieli
- Roberto Littera (ORCID: https://orcid.org/0000-0003-3143-3792)
- Stefano Mocci (ORCID: https://orcid.org/0000-0001-8736-7240)
- Giacomo Mascia
- Paola Del Bianco (ORCID: https://orcid.org/0000-0002-6597-0265)
- Andrea Angioi (ORCID: https://orcid.org/0000-0001-8311-5409)
- C. Sanna
Institutions
- University of Cagliari (IT)
- ATS Sardegna (Italy) (IT)
- Azienda Ospedaliera G. Brotzu (IT)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.ekir.2024.11.893
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00