WCN25-3179 URINARY BIOMARKERS ASSOCIATED WITH DIGITAL PATHOLOGY DESCRIPTORS ASSOCIATE WITH OUTCOMES IN PATIENTS WITH NEPHROTIC SYNDROME

There is a pressing need to develop non-invasive biomarkers that reflect underlying disease mechanisms and serve as substitutes for outcome-related digital pathology descriptors (DPDs). DPDs interstitial fibrosis (IF), tubular atrophy (TA), and mononuclear white blood cells (MWBC) strongly associate with kidney disease outcome in patients with nephrotic syndrome. Due to the invasive nature of kidney biopsy process, it is impractical to perform repeated assessments hence potentially missing crucial periods for early prognosis and intervention.