WCN25-3906 DIFFERENTIAL GENE EXPRESSION AND SIGNAL PATHWAY ACTIVATION LEAD TO DIFFERENCES IN CELL PROLIFERATION AND MIGRATION OF VENOUS AND ARTERIAL PIG SMOOTH MUSCLE CELLS (SMC)

Arteriovenous fistulae (AVF) are the preferred mode of dialysis vascular access but have a maturation failure rate of over 50% due to a venous segment stenosis, which is characterized by smooth muscle cell (SMC) proliferation and migration, resulting in neointimal hyperplasia. Despite the clinical significance of venous segment AVF stenosis, the exact gene expression profile and activation pathways responsible for venous SMC proliferation and migration remain unclear. We herein attempt to identify the differences and similarities of venous versus arterial SMCs.