WCN25-986 CEFTRIAXONE INDUCED THROMBOCYTOPENIA IN END STAGE RENAL DISEASE- A CASE REPORT

Drug induced immune thrombocytopenia is a rare and potentially fatal cause of isolated thrombocytopenia with reported incidence of 10 in one million cases. It is supposed to be caused by formation of drug dependent platelet reactive antibodies leading to increased platelet consumption and destruction. DITP usually occurs within one week of initiation of offending drug and platelet nadir is typically less than 20,000/ul , with or without bleeding manifestations. Prompt discontinuation of inciting drug is the key to resolution and prevention of serious complication like gastrointestinal and intracranial bleeding.