WCN25-2931 pOKRA Study: Biomarker-Based Diagnosis and Histological Correlation of Allograft Rejection in Pediatric Kidney Transplantation
To improve acute rejection(AR) detection in pediatric renal transplants, we propose KidneyCare , combining AlloSure(donor-derived cell-free DNA) and AlloMap(gene expression profiling). AlloMap assesses 5 genes expression, generating a score of 0-20. AlloSure quantifies allograft tissue injury as a percentage of total circulating cell-free DNA.We suggest this combined approach may boost diagnostic accuracy and correlate with Banff lesion intensity
Authors
- Vikas R. Dharnidharka (ORCID: https://orcid.org/0000-0001-8000-1385)
- Jodi M. Smith (ORCID: https://orcid.org/0000-0002-0365-4267)
- Charles W. Goss (ORCID: https://orcid.org/0000-0003-2682-7316)
- Mansi Agarwal (ORCID: https://orcid.org/0000-0002-0367-7733)
- Rouba Garro (ORCID: https://orcid.org/0000-0003-2936-3676)
- Lujain Jaza
- Megan Kelton
- Yasmine Pang
Institutions
- Emory University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.ekir.2024.11.940
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00