WCN25-2942 GLOMERULOSCLEROSIS IS INFLUENCED BY THE MAPK SIGNALING PATHWAY AND THE EGR1 TRANSCRIPTION FACTOR

itself also correlated with impairment of kidney function in renal vasculitis and particularly active glomerular lesions (cellular crescents and necrosis, p<0.0001).Conclusions: The therapeutic implications of targeting uPAR in renal vasculitis are promising, and ongoing research endeavors are aimed at unraveling the complexities of uPAR as a potential diagnostic marker and therapeutic target for this challenging renal pathology.We here expand our current knowledge and link C5aR1 to inflammatory responses driven by glomerular uPAR upregulation in renal vasculitis.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.