WCN25-4516 WHY ARE PREGNANT INDIVIDUALS WITH AKI DYING? AND WHAT CAN WE DO TO SAVE THEM? - RESULTS FROM A PROSPECTIVE COHORT SUTDY

levels were noted: mean TC was 310 AE 30 mg/dL, TG 260 AE 22 mg/dL, LDL 135 AE 12 mg/dL, and VLDL 62 AE 4 mg/dL Preeclampsia was observed in 60.3% of the dyslipidemic group (35 out of 58 patients) compared to 28.6% of the non-dyslipidemic group (12 out of 42 patients) (p < 0.01), indicating a statistically significant association between dyslipidemia and preeclampsia in PRAKI patients.Preterm labor occurred in 74.1% of the dyslipidemic group (43 out of 58 patients) compared to 52.4% of the non-dyslipidemic group (22 out of 42 patients) (p < 0.05), showing a significant association between lipid derangements and preterm labor.Fetal deaths were noted in 77.6% of the dyslipidemic group (45 out of 58 patients) compared to 61.9% of the non-dyslipidemic group (26 out of 42 patients) (p < 0.05).Among the fetal deaths, 73.2% were intrauterine deaths (IUD), and 26.8% were stillbirths.Among live births, 20.6% of the infants were small-for-gestational-age (SGA), predominantly in the dyslipidemic group, with a statistically significant difference compared to the non-dyslipidemic group (p < 0.05).Of the cohort, 53% cases were unbooked, and nine patients succumbed to complications, resulting in a 9% mortality rate.None of them had pancreatitis.By 12 weeks postpartum, all the patients' lipid profiles had returned to normal levels.Conclusions: Dyslipidemia in PRAKI patients is associated with adverse pregnancy outcomes such as preeclampsia, preterm labour, small-for-gestational-age (SGA) and fetal deaths.The high rate of unbooked cases 53% and late referrals to our center underscores the challenges in managing severe cases of PRAKI, which remain difficult for both maternal and neonatal care.There are currently no established guidelines for managing dyslipidemia in patients with pregnancy-related acute kidney injury (PRAKI) during pregnancy and the immediate postpartum period.Therefore, it is recommended that lipid profile screening has to be conducted at the time of conception and closely monitored throughout pregnancy and postpartum to prevent potential complications.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.