WCN25-1565 Dietary Interventions Modulate Immune Metabolism and Fibroblast-to-Myofibroblast Conversion to Attenuate Renal Fibrosis

Renal fibrosis, a hallmark of chronic kidney disease (CKD), is driven by the activation of fibroblasts into myofibroblasts, leading to excessive extracellular matrix deposition and organ dysfunction. Immune cells, particularly T cells, play a critical role in this process through their influence on the microenvironment and cellular metabolism. Emerging evidence suggests that dietary interventions can modulate immune metabolism, potentially altering disease progression. This study investigates the impact of dietary interventions on immune metabolism, fibroblast-to-myofibroblast conversion, and the development of renal fibrosis.