WCN25-1900 Clinical and Safety Outcomes of Semaglutide by CKD Severity in the FLOW trial
Conclusions: Zigakibart was well tolerated and led to sustained, clinically meaningful reductions in proteinuria and eGFR stabilization in patients.The global Phase 3 BEYOND study (NCT05852938) is also evaluating the efficacy and safety of zigakibart in adults with IgAN.This abstract was also submitted for the ASNKidney Week 2024: Barratt J, et al.: A Phase 1/2 Trial of Zigakibart in IgA Nephropathy (IgAN) [Abstract FR-PO856].I have potential conflict of interest to disclose.This study wasfundedbyChinook Therapeutics, ANovartiscompany.I did not use generative AI and AI-assisted technologies in the writing process.
Authors
- Mustafa Kemal Arıcı (ORCID: https://orcid.org/0000-0002-6350-9723)
- Naoki Kashihara (ORCID: https://orcid.org/0000-0002-9487-984X)
- Linong Ji (ORCID: https://orcid.org/0000-0002-3262-2168)
- Søren Rasmussen
- Srikanth Bellary (ORCID: https://orcid.org/0000-0002-5924-5278)
- L. Sreenivasamurthy
- Kenneth W. Mahaffey (ORCID: https://orcid.org/0000-0002-3791-2148)
- Johannes F.E. Mann (ORCID: https://orcid.org/0000-0002-3154-5332)
- Katherine R. Tuttle (ORCID: https://orcid.org/0000-0002-2235-0103)
- Zdravko Asenov Kamenov (ORCID: https://orcid.org/0000-0002-4829-9449)
- Philip Andreas Schytz (ORCID: https://orcid.org/0000-0001-6379-0642)
- Peter R Rossing (ORCID: https://orcid.org/0000-0002-1531-4294)
- Ecenur Guder Arslan
- Vlado Perkovic
- Richard Pratley
- Thomas Idorn (ORCID: https://orcid.org/0009-0009-4896-5868)
Institutions
- Steno Diabetes Centers (DK)
- Aston University (GB)
- Novo Nordisk (Denmark) (DK)
- Kawasaki Medical School (JP)
- Peking University (CN)
- Alexandrovska Hospital (BG)
- UNSW Sydney (AU)
- Peking University People's Hospital (CN)
- Bangalore Diabetes Centre (IN)
- KfH Kuratorium für Dialyse und Nierentransplantation (DE)
- Translational Research Institute for Metabolism and Diabetes (US)
- Stanford Medicine (US)
- Hacettepe University (TR)
- Providence Health & Services (US)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.ekir.2024.11.1358
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00