WCN25-3916 COMPARATIVE ANALYSIS OF ELECTROLYTE TRENDS AND BIOCHEMICAL PARAMETERS IN CHRONIC CALCINEURIN INHIBITOR TOXICITY AND T-CELL MEDIATED REJECTION IN RENAL TRANSPLANT PATIENTS

The kidney plays a vital role in maintaining the body’s electrolyte balance. Renal transplantation offers a lifeline to patients with end-stage renal disease, restoring their ability to regulate electrolytes effectively. Among the leading causes of allograft dysfunction are chronic calcineurin inhibitor (CNI) toxicity and allograft rejection. While CNIs are essential in preventing rejection, they can cause significant electrolyte disturbances. This study aims to analyze the changes in electrolyte trends over time, focusing on sodium (Na), potassium (K), and chloride (Cl), in patients suffering from chronic CNI toxicity compared to those experiencing T-cell mediated rejection (TCMR).