WCN25-2592 Comparison of the Clinical Profile of IgA Nephropathy with Other Primary Glomerulonephritis in Nepalese Patients Undergoing Native Kidney Biopsy

lymphoplasmacytic infiltration with increase in IgG4 positive plasma cells, median 25/high power field (Table 1).Storiform fibrosis was noted in 30.1% biopsies.The interstitial fibrosis and tubular atrophy (IFTA) were mild in 49%, moderate in 16.9% and severe in 33.9% cases.Arteriosclerosis was observed in the vessels of 32% biopsies.No obliterative phlebitis or arteritis was present.The case with membranous nephropathy was negative for PLA2R and NELL-1.The additional pathologic findings in the biopsies included Diabetic nephropathy (11.3%), crescentic glomerulonephritis (3.7%), Focal segmental glomerulosclerosis (1.8%) and acute pyelonephritis (1.8%).Conclusions: This series highlights the heterogeneity of clinical and histopathological features of IgG4 related renal diseases.The pathologic diagnosis provides directions for systemic evaluation and treatment of the patients.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.