WCN25-4104 BK Polyomavirus-Associated Urothelial Carcinoma of the Bladder in Kidney Transplant Recipients – a retrospective look over a 50 year period

Renal transplant recipients are at an increased risk of malignancies. Urothelial carcinoma is not an uncommon malignancy among renal transplant recipients accounting for 12-51% of all malignancies in this setting with significant regional variations. The association of BK polyoma virus(BKPyV) with urothelial cancer (UC) has been described in the past with around 40 cases of UC developing in association with BKPyV being described in literature so far. Histologically, it shows high-grade urothelial carcinoma with a high frequency of glandular differentiation and micropapillary structures and positive immunohistochemistry for polyomavirus large T antigen, p53and p16