WCN25-1022 LONG-TERM KIDNEY FUNCTION BEYOND 12 MONTHS AND KIDNEY RELAPSE AFTER INITIATION OF TREATMENT FOR ANCA-ASSOCIATED VASCULITIS
demonstrated chronic TIN (IF negative) with focal-global glomerulosclerosis in 3 cases. Table. Features of kidney disease in children with APS1 (n7)Kidney diseases, n (q) 7 (1,00)Nephrocalcinosis, n (q) 7 (1,00) Urolitiasis, n (q) 1 (0,14) UTI, n (q) 3 (0,43) RTA, n (q) 3 (0,43) TIN (morphological confirmation), n (q) 3 ( 0,43) eGFR at the first examination (MAEm), ml/min/1/73m2 82AE26 eGFR at the last examination (MAEm), ml/min/1/73m2 55AE18 Conclusions: The data showed that (1) the kidney (along with other organs) is target organ in APS1; (2) the renal dysfunction is diagnosed late in APS1 children; (3) the spectrum of kidney injuries associated with APS1 is mostly represented by nephrocalcinosis (due to treatment of hypoparathyroidism?immune-mediated RTA?); (4) the pts with APS1 had high risk of CKD progression; (5) the regular renal monitoring (including hemogas analysis), close treatment control and interprofessional team management are necessary for any APS1 pts.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.
Authors
- Andreas Kronbichler (ORCID: https://orcid.org/0000-0002-2945-2946)
- Michael Walsh (ORCID: https://orcid.org/0000-0001-8163-183X)
- Zachary S. Wallace (ORCID: https://orcid.org/0000-0003-4708-7038)
- Carol A. McAlear (ORCID: https://orcid.org/0000-0002-0016-6866)
- Mats Junek (ORCID: https://orcid.org/0000-0001-8416-3955)
- Anna Matyjek (ORCID: https://orcid.org/0000-0001-5099-6713)
- Lisa Uchida (ORCID: https://orcid.org/0000-0002-0746-8197)
- Duvuru Geetha (ORCID: https://orcid.org/0000-0001-8353-5542)
- Balazs Odler (ORCID: https://orcid.org/0000-0002-8176-5202)
- David Jayne (ORCID: https://orcid.org/0000-0002-1712-0637)
- Carmel M. Hawley (ORCID: https://orcid.org/0000-0002-1392-5649)
- Vanja Ivković (ORCID: https://orcid.org/0000-0001-9642-4075)
- Peter A. Merkel
Institutions
- Linköping University (SE)
- Innsbruck Medical University (AT)
- Johns Hopkins University (US)
- Universität Innsbruck (AT)
- Medical University of Graz (AT)
- University of Cambridge (GB)
- Hospital of the University of Pennsylvania (US)
- Johns Hopkins Medicine (US)
- Population Health Research Institute (CA)
- Massachusetts General Hospital (US)
- Medical University of Lodz (PL)
- Australasian College for Emergency Medicine (AU)
- University of Pennsylvania (US)
- McMaster University (CA)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.ekir.2024.11.1098
- Citations
- 1
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.52