WCN25-2553 AN OBSERVATIONAL STUDY ON THE CLINICOPATHOLOGIC FEATURES OF RENAL MONOCLONAL IMMUNOGLOBULIN DEPOSITION DISEASE

Monoclonal immunoglobulin deposition disease (MIDD) in kidney is characterised by the deposition of monoclonal immunoglobulins on glomerular basement membrane and tubular basement membrane. Monoclonal immunoglobulins are secreted as a result of clonal proliferation of abnormal plasma cell or B cell lineage. MIDD comprises Light chain deposition disease (LCDD) with deposits of either kappa or lambda, Heavy chain deposition disease (HCDD) with deposits of single heavy chain, Light and heavy chain deposition disease (LHCDD) with deposits of monoclonal light chain and heavy chain.