Efficacy of LaAg Vaccine Associated with Saponin Against Leishmania amazonensis Infection
The LaAg + SAP combination conferred partial protection, as demonstrated by a reduction in lesion size and the partial control of parasite load. In conclusion, the addition of SAP as an adjuvant to LaAg effectively modulates the immune response, enhancing the vaccine's protective efficacy. These findings provide valuable insights into the development of improved vaccines against <i>L.amazonensis</i> infection.
Authors
- Alda Maria Da‐Cruz (ORCID: https://orcid.org/0000-0001-7455-2447)
- Bartira Rossi‐Bergmann (ORCID: https://orcid.org/0000-0002-3791-8996)
- Daniel Cláudio Oliveira Gomes (ORCID: https://orcid.org/0000-0002-0663-0981)
- Luciana Polaco Covre (ORCID: https://orcid.org/0000-0001-5877-0137)
- Monique Pacheco Duarte Carneiro
- Juliana Elena Silveira Pratti
- Herbert Leonel de Matos Guedes (ORCID: https://orcid.org/0000-0002-3819-3069)
- Luan Firmino-Cruz (ORCID: https://orcid.org/0000-0001-8971-8163)
- Eduardo Fonseca Pinto (ORCID: https://orcid.org/0000-0001-7242-4206)
- Tadeu Diniz Ramos (ORCID: https://orcid.org/0000-0002-8523-4361)
- Gabriel Oliveira-Silva
- Alessandra Marcia da Fonseca-Martins (ORCID: https://orcid.org/0000-0003-2043-2217)
- Mirian França de Mello
- Pollyanna Stephanie Gomes (ORCID: https://orcid.org/0000-0002-8283-3369)
- Patrícia de Almeida Machado
- Raquel Peralva
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Universidade Federal do Espírito Santo (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Vaccines
- Published
- 2025-01-27
- DOI
- https://doi.org/10.3390/vaccines13020129
- Citations
- 1
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro