A multi‐cohort study of longitudinal and cross‐sectional Alzheimer's disease biomarkers in cognitively unimpaired older adults
We investigated neuroimaging and cognitive biomarkers in 3036 cognitively unimpaired (CU) participants. Medial temporal lobe (MTL) tau and longitudinal MTL atrophy best separate amyloid beta positive (A+) CU from amyloid beta negative (A-) CU. A- tau positive (T+) CU had a significantly faster neurodegeneration rate compared to A-T- CU. MTL tau correlated with structural magnetic resonance imaging (MRI) and cognition regardless of amyloid beta status. Combined baseline MTL tau, MRI, and cognition best predict Alzheimer's disease progression.
Authors
- Amanda E Denning (ORCID: https://orcid.org/0009-0005-2531-9346)
- Shokufeh Sadaghiani (ORCID: https://orcid.org/0000-0002-2529-5859)
- Long Xie (ORCID: https://orcid.org/0000-0002-7184-7028)
- Ujashi Shah
- Ranjit Ittyerah
- S. J. Wolk (ORCID: https://orcid.org/0000-0002-0826-9261)
- Stanislau Hrybouski
- Pulkit Khandelwal (ORCID: https://orcid.org/0000-0003-1397-3496)
- Eli Gibson (ORCID: https://orcid.org/0000-0001-9207-7280)
- Niyousha Sadeghpour (ORCID: https://orcid.org/0000-0001-8665-0335)
- Lasya P Sreepada (ORCID: https://orcid.org/0000-0001-8000-7074)
- Michael DiCalogero
- Mengjin Dong
- Robin de Florès (ORCID: https://orcid.org/0000-0003-3953-3392)
- Sandhitsu R. Das (ORCID: https://orcid.org/0000-0003-0530-2887)
- Laura E.M. Wisse (ORCID: https://orcid.org/0000-0001-7504-3943)
- Paul A. Yushkevich (ORCID: https://orcid.org/0000-0001-8543-4016)
- Jesse Cohen (ORCID: https://orcid.org/0000-0003-2554-5181)
- Xueying Lyu (ORCID: https://orcid.org/0000-0002-2885-3940)
- Christopher Brown (ORCID: https://orcid.org/0000-0003-2057-3976)
- Sadhana Ravikumar (ORCID: https://orcid.org/0000-0002-9858-4731)
- Yue Li (ORCID: https://orcid.org/0009-0005-8870-3898)
- Emily McGrew
- Ademola Ilesanmi
Institutions
- Inserm (FR)
- Lund University (SE)
- Penn Center for AIDS Research (US)
- Siemens (United States) (US)
- Siemens Healthcare (United States) (US)
- University of Pennsylvania (US)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1002/alz.14492
- Citations
- 9
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 13.24
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Brigham and Women's Hospital
- Massachusetts General Hospital
- Biogen
- University of Southern California
- BrightFocus Foundation
- Meso Scale Diagnostics
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Fred A. And Barbara M. Erb Family Foundation
- GHR Foundation
- Lewy Body Dementia Association
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- Fondation Philippe Chatrier
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research