Malnutrition exacerbating neuropsychiatric symptoms on the Alzheimer's continuum is relevant to the cAMP signaling pathway: Human and mouse studies
Poor nutritional status linked to general and specific neuropsychiatric symptom (NPS) deterioration. Malnutrition affects NPSs, usually involving the midbrain and striatum. Malnourished diet induces depression- and anxiety-like behaviors in APP/PS1 mice. Malnutrition exacerbates NPSs associated with cAMP signaling pathway in the midbrain and striatum.
Authors
- Min Zhao (ORCID: https://orcid.org/0000-0002-4551-043X)
- Xiaoli Zhang (ORCID: https://orcid.org/0009-0003-8986-3119)
- Jun Xu (ORCID: https://orcid.org/0000-0001-7432-6781)
- Tianlin Jiang (ORCID: https://orcid.org/0000-0002-7844-3624)
- Hanping Shi (ORCID: https://orcid.org/0000-0003-4514-8693)
- Zeshan Yao
- Jiwei Jiang (ORCID: https://orcid.org/0000-0001-5775-2754)
- Jianyin Zhou (ORCID: https://orcid.org/0000-0002-4396-4518)
- Linlin Wang (ORCID: https://orcid.org/0000-0002-5433-6410)
- Xiaohong Wang
- Wenyi Li (ORCID: https://orcid.org/0000-0001-9104-4567)
- Huiying Zhang (ORCID: https://orcid.org/0000-0002-5528-4712)
- Shiyi Yang
- Qiwei Ren
- Yaou Liu
- Shirui Jiang (ORCID: https://orcid.org/0000-0002-3324-7785)
Institutions
- Capital Medical University (CN)
- China International Science and Technology Cooperation (CN)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Beijing Shijitan Hospital (CN)
- South China Institute of Collaborative Innovation (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1002/alz.14506
- Citations
- 5
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- National Key Research and Development Program of China