Insights Into Causal Effects of Genetically Proxied Lipids and Lipid‐Modifying Drug Targets on Cardiometabolic Diseases
The study substantiates the causal role of lipids in specific cardiometabolic diseases, highlighting LPL as a potent drug target. The effects of LPL are suggested to be influenced by changes in glucose and blood pressure, providing insights into its mechanism of action.
Authors
- Liwan Fu (ORCID: https://orcid.org/0000-0002-7851-6379)
- Jie Mi (ORCID: https://orcid.org/0000-0003-0630-8447)
- Jingfan Xiong (ORCID: https://orcid.org/0009-0008-9126-1738)
- Xiaoyuan Zhao (ORCID: https://orcid.org/0000-0002-8628-2023)
- Qin Liu (ORCID: https://orcid.org/0000-0002-0891-2325)
- Hong Cheng (ORCID: https://orcid.org/0000-0002-6341-541X)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Capital Medical University (CN)
- Capital Institute of Pediatrics (CN)
- Beijing Children’s Hospital (CN)
- Children's Hospital of Capital Institute of Pediatrics (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1161/jaha.124.038857
- Citations
- 3
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- National Natural Science Foundation of China
- Sanming Project of Medicine in Shenzhen