Alternative Complement Pathway in Carotid Atherosclerosis: Low Plasma Properdin Levels Associate With Long‐Term Cardiovascular Mortality
We show a strong and independent association of low plasma properdin levels with cardiovascular mortality in 2 cohorts. Conversely, the plaque properdin levels linked to features of plaque vulnerability, potentially reflecting increased deposition at the site of inflammation or local production of properdin in the atherosclerotic lesion indicating local enhanced alternative complement pathway activation.
Authors
- Andreas Edsfeldt (ORCID: https://orcid.org/0000-0002-2691-9192)
- Mieke C. Louwe (ORCID: https://orcid.org/0000-0002-4797-4991)
- Pål Aukrust
- Sverre Holm (ORCID: https://orcid.org/0000-0003-1064-3926)
- Bente Lise Halvorsen (ORCID: https://orcid.org/0000-0002-6529-6485)
- Tom Eirik Mollnes (ORCID: https://orcid.org/0000-0002-5785-802X)
- Thor Ueland (ORCID: https://orcid.org/0000-0001-5005-0784)
- Maria Belland Olsen
- Peter Libby (ORCID: https://orcid.org/0000-0002-1502-502X)
- Per H. Nilsson (ORCID: https://orcid.org/0000-0002-7192-5794)
- Isabel Gonçalves (ORCID: https://orcid.org/0000-0002-2935-0181)
- Xiang Yi Kong (ORCID: https://orcid.org/0000-0003-3244-344X)
- Annika E. Michelsen (ORCID: https://orcid.org/0000-0001-7207-2407)
- Chrysostomi Gialeli (ORCID: https://orcid.org/0000-0003-4290-9610)
- Mona Skjelland (ORCID: https://orcid.org/0000-0001-7950-4882)
- Karolina Skagen (ORCID: https://orcid.org/0000-0002-6540-3463)
- Tove Lekva (ORCID: https://orcid.org/0000-0002-7962-4726)
- Tuva Børresdatter Dahl (ORCID: https://orcid.org/0000-0001-7818-9411)
- Kristine Stø (ORCID: https://orcid.org/0000-0001-5140-8709)
- Vigdis Bjerkeli
- Therese Schjørlien
Institutions
- Oslo University Hospital (NO)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Oslo (NO)
- Lund University (SE)
- Norwegian University of Science and Technology (NO)
- Linnaeus University (SE)
- Nordland Hospital (NO)
- Skåne University Hospital (SE)
- UiT The Arctic University of Norway (NO)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1161/jaha.124.038316
- Citations
- 6
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- Stiftelsen för Strategisk Forskning
- Lunds Universitet
- Svenska Sällskapet för Medicinsk Forskning
- Knut och Alice Wallenbergs Stiftelse
- Novo Nordisk
- Vetenskapsrådet
- Norges Forskningsråd
- Svenska Läkaresällskapet
- STROKE-Riksförbundet
- Skånes universitetssjukhus
- Helse Sør-Øst RHF