Single-cell transcriptomics identify a novel macrophage population associated with bone invasion in pituitary neuroendocrine tumors
Our study elucidates the tumor microenvironment changes in bone invasion and identifies the critical role of TNF-α<sup>+</sup> TAMs in promoting bone invasion of PitNETs, laying a foundation for developing new molecular markers or therapeutic agents targeting BI PitNETs.
Authors
- Chuzhong Li (ORCID: https://orcid.org/0000-0002-0256-1261)
- Lei Gong (ORCID: https://orcid.org/0000-0001-8846-6590)
- Mingxuan Li (ORCID: https://orcid.org/0000-0002-8382-1124)
- Weiyan Xie (ORCID: https://orcid.org/0000-0001-6029-8521)
- Yazhuo Zhang (ORCID: https://orcid.org/0000-0002-5290-4314)
- Haibo Zhu (ORCID: https://orcid.org/0000-0003-3138-437X)
- Xinzhi Wu
- Xueshuai Han (ORCID: https://orcid.org/0000-0002-9931-0150)
- Shanghua Jing (ORCID: https://orcid.org/0000-0003-4515-2094)
- Zhaoqi Liu (ORCID: https://orcid.org/0009-0002-9645-4922)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- Beijing Institute of Genomics (CN)
- University of California San Diego (US)
- Beijing Tian Tan Hospital (CN)
- Beijing Institute of Neurosurgery (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1186/s13046-025-03296-9
- Citations
- 4
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.18
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences