A framework of biomarkers for skeletal muscle aging: a consensus statement by the Aging Biomarker Consortium
The skeletal muscle is an important organ for movement and metabolism in human body, and its physiological aging underlies the occurrence of muscle atrophy and sarcopenia. China has the largest aging population in the world and is facing a grand challenge with how to prevent and treat skeletal muscle aging-related diseases. To address this difficult problem, the Aging Biomarker Consortium (ABC) of China has reached an expert consensus on biomarkers of skeletal muscle aging by synthesizing literatures and insights from scientists and clinicians. This consensus attempts to provide a comprehensive assessment of biomarkers associated with skeletal muscle aging, and proposes a systematic framework to classify them into three dimensions: functional, structural, and humoral. Within each dimension, the experts recommend clinically relevant biomarkers for skeletal muscle aging. This consensus aims to lay the foundation for future research on skeletal muscle aging, facilitating precise prediction, diagnosis, and treatment of skeletal muscle aging and sarcopenia. It is anticipated to make significant contributions to healthy aging of skeletal muscle in the elderly population in China and around the world as well.
Authors
- Jirong Yue (ORCID: https://orcid.org/0000-0002-3730-779X)
- Xu Tian (ORCID: https://orcid.org/0000-0002-4508-8347)
- Qian Xiao (ORCID: https://orcid.org/0000-0001-8855-6561)
- Ng Shyh‐Chang (ORCID: https://orcid.org/0000-0003-3138-9525)
- Huating Wang (ORCID: https://orcid.org/0000-0001-5474-2905)
- Zhenji Gan (ORCID: https://orcid.org/0000-0001-5940-207X)
- Rui Yue (ORCID: https://orcid.org/0000-0002-3401-369X)
- Jing Qu (ORCID: https://orcid.org/0000-0002-3988-5067)
- Ning Huang (ORCID: https://orcid.org/0000-0001-5413-6825)
- Lunzhi Dai (ORCID: https://orcid.org/0000-0002-3003-8910)
- Hongbo Zhang (ORCID: https://orcid.org/0000-0002-4081-5752)
- Pengbin Yin (ORCID: https://orcid.org/0000-0002-5391-4477)
- Dahai Zhu (ORCID: https://orcid.org/0009-0000-8349-666X)
- Yong Liu (ORCID: https://orcid.org/0000-0001-7771-4181)
- Yong Zhang (ORCID: https://orcid.org/0000-0002-2443-5143)
- Xiaolei Liu (ORCID: https://orcid.org/0000-0003-4337-0899)
- Licheng Zhang (ORCID: https://orcid.org/0000-0002-6782-1749)
- Biao Dong (ORCID: https://orcid.org/0000-0002-5991-1867)
- Weiqi Zhang (ORCID: https://orcid.org/0000-0002-8885-5104)
- Si Wang (ORCID: https://orcid.org/0000-0003-2431-0612)
- Guang‐Hui Liu (ORCID: https://orcid.org/0000-0001-9289-8177)
- Zhijun Bao (ORCID: https://orcid.org/0000-0002-1382-5306)
- Gang Pei
- Ping Hu (ORCID: https://orcid.org/0000-0001-8832-1391)
- Birong Dong (ORCID: https://orcid.org/0000-0002-3655-3155)
- Meiling Ge
Institutions
- Tongji University (CN)
- Sun Yat-sen University (CN)
- Chinese University of Hong Kong (HK)
- Shanghai Jiao Tong University (CN)
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- Fudan University (CN)
- Netaji Subhas National Institute of Sports (IN)
- XinHua Hospital (CN)
- Beijing Institute of Genomics (CN)
- Chinese PLA General Hospital (CN)
- Wuhan University (CN)
- Guangzhou University (CN)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- National Clinical Research Center for Digestive Diseases (CN)
- West China Hospital of Sichuan University (CN)
- Guangzhou Experimental Station (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Huadong Hospital (CN)
- Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN)
- EarthTech International (United States) (US)
- Nanjing Drum Tower Hospital (CN)
- Prince of Wales Hospital (CN)
- National Clinical Research (US)
- Shanghai East Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Model Animal Research Center (CN)
- Shanghai Tenth People's Hospital (CN)
- National Center for Geriatrics and Gerontology (JP)
- Center for Life Sciences (CN)
- University of Chinese Academy of Sciences (CN)
- Best Biotech (US)
- Institute of Zoology (CN)
- State Key Laboratory of Stem Cell and Reproductive Biology
- State Key Laboratory of Biotherapy
- Chongqing Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Life Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1093/lifemedi/lnaf001
- Citations
- 12
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 3.92
Funders
- National Natural Science Foundation of China
- West China Hospital, Sichuan University