Using Laboratory Test Results for Surveillance During a New Outbreak of Acute Hepatitis in 3-Week- to 5-Year-Old Children in the United Kingdom, the Netherlands, Ireland, and Curaçao: Observational Cohort Study
Hospital laboratories collect large amounts of data on a daily basis that can potentially be of use for disease surveillance, but these are currently not optimally used. Federated analytics using nondisclosive, summary-level laboratory data sharing was successful, safe, and efficient. The approach holds potential as a tool for pandemic surveillance in future outbreaks. Our findings do not indicate the presence of a broader outbreak of mild hepatitis cases among young children, although there was an increase in elevated AST or ALT values locally in the Netherlands.
Authors
- Diederik Brandwagt (ORCID: https://orcid.org/0000-0003-4895-1756)
- Pieter L.A. Fraaij
- Leo G. Visser (ORCID: https://orcid.org/0000-0002-3600-9782)
- Seb Bacon (ORCID: https://orcid.org/0000-0002-6354-3454)
- J. Kenneth Baillie (ORCID: https://orcid.org/0000-0001-5258-793X)
- Amir Mehrkar (ORCID: https://orcid.org/0000-0002-2098-1278)
- Merel van Wijnen (ORCID: https://orcid.org/0000-0002-6676-1238)
- Louis Fisher (ORCID: https://orcid.org/0000-0002-0295-3812)
- Alistair Nichol (ORCID: https://orcid.org/0000-0002-4689-1238)
- Ben Goldacre (ORCID: https://orcid.org/0000-0002-5127-4728)
- Maaike Swets (ORCID: https://orcid.org/0000-0003-0901-9560)
- Philippa Clare Matthews (ORCID: https://orcid.org/0000-0002-4036-4269)
- Malcolm Gracie Semple (ORCID: https://orcid.org/0000-0001-9700-0418)
- Brian MacKenna (ORCID: https://orcid.org/0000-0002-3786-9063)
- Patrick J. Twomey (ORCID: https://orcid.org/0000-0001-7284-4673)
- Paul W. Schenk (ORCID: https://orcid.org/0000-0001-8155-9073)
- Geert H. Groeneveld (ORCID: https://orcid.org/0000-0001-6529-1396)
- Iain Jones (ORCID: https://orcid.org/0000-0002-8217-5052)
- Steven Kerr (ORCID: https://orcid.org/0000-0002-3643-7859)
Institutions
- University College Dublin (IE)
- Roslin Institute (GB)
- University of Liverpool (GB)
- Leiden University Medical Center (NL)
- The Francis Crick Institute (GB)
- Erasmus MC (NL)
- Edinburgh Royal Infirmary (GB)
- University of Oxford (GB)
- Australian and New Zealand Intensive Care Society (AU)
- National Institute for Public Health and the Environment (NL)
- St. Vincent's University Hospital (IE)
- Centre for Inflammation Research (GB)
- Meander Medisch Centrum (NL)
- Queen Elizabeth University Hospital (GB)
- Institute of Genetics and Cancer (GB)
- Monash University (AU)
- University of Edinburgh (GB)
Publication Details
- Journal
- JMIR Public Health and Surveillance
- Published
- 2024-12-23
- DOI
- https://doi.org/10.2196/55376
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- UK Research and Innovation
- National Institute for Health Research Health Protection Research Unit
- National Institute for Health and Care Research
- University of Liverpool
- Intensive Care Society
- Medical Research Council
- Biotechnology and Biological Sciences Research Council