CASC8 activates the pentose phosphate pathway to inhibit disulfidptosis in pancreatic ductal adenocarcinoma though the c-Myc-GLUT1 axis
This study provides evidence for the existence of disulfidptosis in PDAC and reveals the upregulation of CASC8 in this malignancy. Furthermore, we demonstrate that CASC8 acts as a crucial regulator of the pentose phosphate pathway and disulfidptosis, thereby promoting PDAC progression.
Authors
- Guihua Zhou (ORCID: https://orcid.org/0000-0001-8867-8008)
- Chunjing Li (ORCID: https://orcid.org/0000-0002-4212-2386)
- Xiao Hu (ORCID: https://orcid.org/0000-0003-1128-4099)
- Hong‐Fei Yao (ORCID: https://orcid.org/0009-0008-6076-4295)
- Jiahao Chen (ORCID: https://orcid.org/0000-0001-7719-3216)
- Jieqiong Ge
- Zhiwei Cai (ORCID: https://orcid.org/0009-0008-4859-4131)
- Xiaoyan Tang (ORCID: https://orcid.org/0000-0001-5171-3025)
- Tongyi Zhang (ORCID: https://orcid.org/0000-0002-7908-8046)
- Chongyi Jiang
- Yunlong Pu
- Abousalam Abdoulkader Ahmed
Institutions
- Fudan University (CN)
- Huadong Hospital (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1186/s13046-025-03295-w
- Citations
- 11
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 11.50
Funders
- National Natural Science Foundation of China