Association of Alzheimer’s and Lewy body disease pathology with basal forebrain volume and cognitive impairment
In a heterogeneous autopsy sample, AD and LB pathology both contribute to cholinergic basal forebrain degeneration whereas hippocampus atrophy is more specifically related to AD pathology. Cognitive deficits are primarily associated with tau pathology which is partly mediated by hippocampus, but not basal forebrain atrophy.
Authors
- Stefan Johannes Teipel (ORCID: https://orcid.org/0000-0002-3586-3194)
- Alexander Storch (ORCID: https://orcid.org/0000-0002-1133-9216)
- Julia Schumacher (ORCID: https://orcid.org/0000-0001-7323-4789)
Institutions
- German Center for Neurodegenerative Diseases (DE)
- University of Rostock (DE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1186/s13195-025-01678-x
- Citations
- 9
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 13.24
Funders
- National Institutes of Health
- National Institute on Aging