[Knockdown of <i>NPTX1</i> promotes osteogenic differentiation of human bone marrow mesenchymal stem cells].

<i>NPTX1</i> exerts a modulatory role in the osteogenic differentiation of hBMSCs, and its knockdown has been found to enhance the osteogenic differentiation of hBMSCs. This finding implies that <i>NPTX1</i> could potentially serve as a therapeutic target for the treatment of osteogenic abnormalities, including osteoporosis.

Authors

Ting Shuai (ORCID: https://orcid.org/0000-0002-3870-704X)
Chunping Lin
Yanyan Guo (ORCID: https://orcid.org/0000-0002-0175-677X)
Chanyuan Jin (ORCID: https://orcid.org/0000-0003-0022-5229)
Xiaomei Hou

Institutions

Fujian Medical University (CN)
National Clinical Research Center for Digestive Diseases (CN)
National Clinical Research (US)
Fujian Provincial Hospital (CN)

Publication Details

Journal: PubMed
Published: 2025-02-18
DOI: https://doi.org/10.19723/j.issn.1671-167x.2025.01.002
Primary Topic: Bone Metabolism and Diseases
Type: article

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article

[Knockdown of NPTX1 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells].

Ting Shuai, Chunping Lin, Yanyan Guo, Chanyuan Jin et al.

Feb 18, 2025

PubMed

Bone Metabolism and Diseases

article

[Knockdown of NPTX1 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells].

Ting Shuai, Chunping Lin, Yanyan Guo, Chanyuan Jin, Xiaomei Hou

February 18, 2025article en

Abstract

<i>NPTX1</i> exerts a modulatory role in the osteogenic differentiation of hBMSCs, and its knockdown has been found to enhance the osteogenic differentiation of hBMSCs. This finding implies that <i>NPTX1</i> could potentially serve as a therapeutic target for the treatment of osteogenic abnormalities, including osteoporosis.

PubMedVol. 57(1)

Fujian Medical University (CN), National Clinical Research Center for Digestive Diseases (CN), National Clinical Research (US), Fujian Provincial Hospital (CN)

Bone Metabolism and Diseases

DOI Open Access PDF OpenAlex

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[Knockdown of <i>NPTX1</i> promotes osteogenic differentiation of human bone marrow mesenchymal stem cells]. — Ting Shuai, Chunping Lin, et al. · PubMed (2025) | TGRS Research Map | TGRS