Calycosin extracted from Astragali Radix reduces NETs formation to improve renal fibrosis via TLR4/NF-κB pathway
Our findings revealed that calycosin reduces NETs production to alleviate renal fibrosis via TLR4 and NF-κB, supporting its potential as a strategy for treating renal fibrosis.
Authors
- Huifan Yu (ORCID: https://orcid.org/0000-0003-2936-5778)
- Mao Xu
- Wenjie Cao (ORCID: https://orcid.org/0000-0002-7877-4079)
- Linsheng Huang
- Fei Li (ORCID: https://orcid.org/0000-0003-2016-6422)
- Li Liu (ORCID: https://orcid.org/0000-0002-6645-1352)
- Hong Zhou (ORCID: https://orcid.org/0000-0001-8389-8802)
- Siyi Li (ORCID: https://orcid.org/0000-0003-4916-8253)
- Yongshuai Qian
Institutions
- Hubei University of Medicine (CN)
- Peking University (CN)
- Hubei University of Chinese Medicine (CN)
- Taihe Hospital (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1016/j.jep.2025.119391
- Citations
- 8
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 11.45
Funders
- Hubei Provincial Department of Education
- Hubei University of Medicine