SUMO-Specific Peptidase 5 Promotes Oesophageal Squamous Cell Carcinoma Growth through the NF-κB-SLC1A3 Axis
Suppression of SENP5 slows the development of ESCC by inhibiting the NF-κB<i>‒SLC1A3</i> axis through SUMO1-mediated SUMOylation of IκBα. Our research suggests that SENP5 could serve as a prognostic indicator and a target for therapeutic intervention for ESCC patients.
Authors
- Lijie Tan
- Shaoyuan Zhang (ORCID: https://orcid.org/0000-0002-6187-4313)
- Guiping Yu (ORCID: https://orcid.org/0000-0002-6806-513X)
- Chaoxiang Du
- Renfeng Wang
- Tao Zhang (ORCID: https://orcid.org/0000-0002-5607-4610)
- Zhe Zhang (ORCID: https://orcid.org/0000-0003-4208-8461)
- Jianmin Gu (ORCID: https://orcid.org/0000-0002-3536-0562)
- Xinyu Yang
- Yunfan Hu (ORCID: https://orcid.org/0009-0006-2127-4125)
Institutions
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Jiangyin People's Hospital (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-01-22
- DOI
- https://doi.org/10.31083/fbl27047
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00