Chemical Warfare Agent: Toxicity and Health Effects of Sarin Gas (GB)

Chemical warfare agents (CWAs) are toxic substances used to cause harm, injury, or incapacitation to an adversary in the context of warfare and related military activities. Sarin stands as an exemplar among agents, embodying some of the most potent compounds ever developed. This strength originates from its ability to permanently inhibit the acetylcholinesterase (AChE) enzyme, leading to the accumulation of acetylcholine (ACh) at synaptic junctions, which, in turn, induces stimulation of muscarinic and nicotinic receptors. The main objective of the current article is to summarize the negative influence of sarin gas on health and its role in the incidence of several pathological conditions in people who’s exposed to the gas. From this point of view, the clinical features of sarin exposure (health effect and related diseases) and the influence of nerve agents on deactivation of cholinesterase were the main area covered in this article. Furthermore, and for better understanding of the gas behavior and its toxicity, it was important to discuss the features of the gas, discovery, mechanism of toxicity, and pharmacological management. Lately, various approaches have also been reported with esteem of sarin detection, destruction, attacks, and treatment approaches after sarin poisoning.