Cover Feature: Isolation, Structure Elucidation, and Biological Activity of the Selective TACR2 Antagonist Tumonolide and its Aldehyde from a Marine Cyanobacterium (Chem. Eur. J. 50/2024)

Marine natural product on target: GPCRs are prime targets for drug discovery, representing targets of over 40 % of approved drugs. The cover illustrates tumonolide, a new marine natural product, docked into the binding pocket of the tachykinin receptor 2 (TACR2). The TACR2-selective GPCR inhibitor was isolated from a marine cyanobacterium, and its structure, including the absolute configuration depicted on the ocean floor, was elucidated through various spectroscopic and computational methods. More information can be found in the Research Article by H. Luesch and co-workers (DOI: 10.1002/chem.202401393).