THE IMMUNOMODULATORS COMBINED USE INFLUENCE ON THE NON-SPECIFIC RESISTANCE IN CALVES IN THE EARLY POSTNATAL REARING PERIOD

he purpose of research is to study the effect of the combined use of immunomodulators on the nonspecific resistance of calves in the early postnatal period of growing. Objectives: to study the dynamics of morpho-biochemical, immunological blood parameters with the combined use of immunomodulators in calves in the early postnatal period of rearing; to determine the optimal combination, the frequency of administration of immunomodulators to calves in the early postnatal period, to increase nonspecific resistance. Research and production experience was carried out on calves of black-motley breed in the early postnatal period of rearing in the Altai Region. In accordance with the tasks, 6 groups of experimental animals were formed, one of which was a control group. Calves of the control group were injected with saline at a dose of 5.0 ml. For calves of the experimental groups, respectively, immunomodulators were injected in a certain sequence and combination. Based on the results obtained, on the use of immunomodulators to increase the nonspecific resistance of the calf organism, the best protocol is a double alternation of injections of fosprenil – immunofan – fosprenil – immunofan with an interval of 6–2–6 days (O-3). In animals of this group, the maximum increase in the total amount of protein (by 4.5 %), albumin (by 1.8 %) was noted, which indicates the activation and improvement of metabolic processes. The bactericidal activity of the blood serum of calves throughout the experiment was within the physiological norm, with a slight decrease in gamma globulin 0.4 and an increase of lysozyme activity by 21.3 %, which indicates positive compensatory reactions and the level of nonspecific resistance of the animal organism, helps to reduce the incidence by 60.0 % and an increase in safety up to 100.0 %.