Preparation and Characterization of a Novel Cooling Agent With Intelligent Response Long‐Term Release Effect

ABSTRACT Coolant, a general term for all chemical substances that produce a cooling effect without strong medicinal properties. Currently reported coolants are generally used as additives directly in food and daily chemicals. Here we pioneered a responsive nanoscale formulation to improve the application limitations of coolants. The cooling agent consists of 1,3‐propanediol, high‐substituted hydroxypropyl cellulose(H‐HPC), and three coolants, utilizing H‐HPC as the polymer shell that encapsulates and releases the coolants. It has long‐lasting release properties and can be released immediately upon contact with water through the vesicle structure formed by H‐HPC. The cooling agent has a particle size between 20 and 60 nm, a pH between 6.16 and 7.28, a refractive index between 1.400 and 1.500, a viscosity between 1500 and 3000 mPa s, and a good stability without precipitation and delamination after centrifugation. Meanwhile, the cold stimulation neuron test shows the excellent performance of longer duration and better effect than menthol cooling sensation. Its good formulation application shows a better application prospect in cosmetics and light chemical industry.