A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator
Results highlight the impact of adiposity on the plasma proteome and of adiposity-associated circulating proteins on the risk of CRC. Supported by evidence from UVMR and colocalization analyses using cis-single-nucleotide polymorphisms, GREM1 was identified as a potential mediator of the BMI-CRC association, particularly in women.
Authors
- Sun‐Seog Kweon (ORCID: https://orcid.org/0000-0003-2378-8550)
- Bethany Van Guelpen (ORCID: https://orcid.org/0000-0002-9692-101X)
- Matthew A. Lee (ORCID: https://orcid.org/0000-0001-6262-3447)
- Charlie Hatcher (ORCID: https://orcid.org/0000-0002-5952-4816)
- Karl Smith-Byrne (ORCID: https://orcid.org/0000-0002-1932-7463)
- Polly A. Newcomb (ORCID: https://orcid.org/0000-0001-8786-0043)
- Ulrike Peters (ORCID: https://orcid.org/0000-0001-5666-9318)
- Neil Murphy (ORCID: https://orcid.org/0000-0003-3347-8249)
- Richard Michael Martin (ORCID: https://orcid.org/0000-0002-7992-7719)
- Lucy J. Goudswaard (ORCID: https://orcid.org/0000-0003-1481-6871)
- Iona C. Cheng (ORCID: https://orcid.org/0000-0003-4132-2893)
- Robert E. Schoen (ORCID: https://orcid.org/0000-0001-7153-2766)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Hermann Brenner (ORCID: https://orcid.org/0000-0002-6129-1572)
- Emma E. Vincent (ORCID: https://orcid.org/0000-0002-8917-7384)
- Emma Hazelwood (ORCID: https://orcid.org/0000-0002-4888-6037)
- Konstantinos K Tsilidis
- L. Le Marchand
Institutions
- University of Hawaiʻi at Mānoa (US)
- University of Hawaii System (US)
- German Cancer Research Center (DE)
- University of California, San Francisco (US)
- University of Ioannina (GR)
- University of Washington (US)
- Heidelberg University (DE)
- University Hospitals Bristol NHS Foundation Trust (GB)
- National Institute for Health and Care Research (GB)
- University of Bristol (GB)
- University of Oxford (GB)
- Fred Hutch Cancer Center (US)
- Chonnam National University Hospital (KR)
- Cancer Center of Hawaii (US)
- National Center for Tumor Diseases (DE)
- NIHR Bristol Biomedical Research Centre (GB)
- Regional Cancer Center (US)
- University of Pittsburgh Medical Center (US)
- Chonnam National University Hwasun Hospital (KR)
- Centre international de recherche sur le cancer (FR)
- University of Hawaii Cancer Center
- Imperial College London (GB)
- Umeå University (SE)
- Medical Research Council (GB)
Publication Details
- Journal
- International Journal of Epidemiology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1093/ije/dyae175
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- World Cancer Research Fund International
- Cancer Research UK
- Cancerfonden
- Institut National Du Cancer
- Wereld Kanker Onderzoek Fonds
- Medical Research Council
- World Cancer Research Fund
- National Cancer Institute